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Japanese researchers say mental stress can lead to hyperglycemia and hyperlipidemia

January 20, 2023
Hyperglycemia and hyperlipidemia are common lifestyle diseases, and mental states are thought to have a deep relationship with lifestyle diseases. Researchers from Nagoya University in Japan announced that they found that nervous tension can cause visceral fat inflammation in animal experiments, leading to hyperglycemia and hyperlipidemia.

The researchers allowed the mice to stay in a narrow cylinder of 3 cm in diameter for 2 hours per day, allowing the mice to be in constant nervous stress for two consecutive weeks. As a result, it was found that hormones secreted by the mouse adrenal cortex and the like lead to the decomposition and atrophy of visceral fat, and the amount of "MCP-1" protein that causes inflammation in the cells and in the blood increases, resulting in inflammation of visceral fat. Compared with normal mice, mentally stressed mice have lower insulin secretion and it is difficult to absorb sugar from the blood into the cells. Blood clots easily and blood clots appear.

The researchers also found that the function of fat inflammation and insulin secretion was improved if aerobically stressed mice were injected with adipose-derived stem cells capable of suppressing the function of the "MCP-1" protein. The related papers were published on the online edition of Diabetes magazine.
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